My research program investigates how and why insulin-producing beta cells in the pancreas are targeted and destroyed by autoimmunity in Type 1 Diabetes (T1D). We carry out basic and translational research studies using cell culture, mouse models and human donor tissue and specimens to examine islet stress pathways, interactions with the immune system and explore biomarkers for disease progression. Our … Read More
Lucy Marzban, DMLS PhD
Pancreatic islet transplantation has provided a feasible approach for replacement of insulin-producing beta cells in patients with type 1 diabetes (T1D) but is currently limited by short supply and post-transplant loss of islets. My research program focuses on understanding the factors that destroy islet beta-cells following transplantation, potentially leading to islet graft failure. Specifically, we aim to identify the mechanisms … Read More
Christine Doucette, PhD
Research in the Doucette Lab is focused on defining the molecular and metabolic factors that regulate pancreatic insulin secretion and importantly, learning how these factors are disrupted in the development of type 2 diabetes. Being a pre-clinical laboratory, Dr. Christine Doucette and her team use rodent and cell models to “reverse engineer” diabetes so they can explore the pathological mechanisms … Read More